Antioxidant Activity of Imidazole Dipeptides

Ewa Biazik , Wiesław Kopeć

Abstract

In this chapter we describe the antioxidant activity of imidazole dipeptides and some selected derivatives in various experimental systems, including liposomes, lipids, tissues and protein models. Structures containing an imidazole ring, mainly carnosine-related compounds, are well-known antioxidants. In particular, these properties of imidazole dipeptides are commonly investigated in metal-related liposome model systems. However, the effect of dose dependency and compound type is different in every case. This suggests that the mechanism of antioxidant action proceeds via many paths based on reactions with secondary and final products of peroxidation and some initiators, such as transition metals. Particular attention is paid to free-radical scavenging activity and the ability to trap aldehydic compounds. Also, the properties of some new derivatives, such as pseudopeptides, various acetylated derivatives and β-cyclodextrine conjugates of histidine dipeptides, are shown.
Author Ewa Biazik (EaE / IChaFT / KAJ)
Ewa Biazik,,
- Katedra Analizy Jakości
, Wiesław Kopeć
Wiesław Kopeć,,
-
Pages2017-234
Publication size in sheets0.3
Book Preedy Vistor R. (eds.): Imidazole Dipeptides : Chemistry, Analysis, Function and Effects, 2015, Royal Society of Chemistry Publishing, ISBN 9781849738903, [9781782626558], 602 p., DOI:10.1039/9781782622611
DOIDOI:10.1039/9781782622611-00217
URL http://pubs.rsc.org/en/content/chapter/bk9781849738903-00217/978-1-84973-890-3#!divabstract
Languageen angielski
Score (nominal)0
ScoreMinisterial score = 0.0, 02-07-2019, MonographChapterAuthor
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