Paucity of Tumor-infiltrating Lymphocytes Is an Unfavorable Prognosticator and Predicts Lymph Node Metastases in Cutaneous Melanoma Patients

Piotr Donizy , Maciej Kaczorowski , Agnieszka Hałoń , Marek Leśkiewicz , Cyprian Kozyra , Rafał Matkowski

Abstract

Background/Aim: Tumor infiltrating lymphocytes (TILs) have been a subject of growing scientific interest; however, a full picture of their role in cancer pathogenesis is still unclear. The present study aimed to reveal correlations between TIL grade and clinicopathological features, especially 5-year survival parameters in cutaneous malignant melanoma (CMM) patients. Materials and Methods: Presence of TILs was assessed by hematoxylin and eosin staining in routine diagnostic histopathological specimens from 104 patients with cutaneous melanoma. Results: In the entire group of 104 patients, decreasing TIL intensity was a highly negative prognostic factor and indicated considerably shorter overall survival (OS), cancer-specific overall survival (CSOS) and disease-free survival (DFS). We also report on a significant association between decreased TIL intensity and worse prognosis in lymph node-negative patients. Shorter survival (p=0.002 for OS, p=0.038 for CSOS and p=0.011 for DFS) was observed in patients with negative sentinel lymph node biopsies (SLNB), as well as in patients with lack of metastases in regional lymph nodes (p=0.034 for OS, p<0.001 for CSOS and DFS). Conclusion: Our results indicate that TIL grade is a valuable diagnostic parameter that may be helpful in risk stratification in CMM
Author Piotr Donizy
Piotr Donizy,,
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, Maciej Kaczorowski
Maciej Kaczorowski,,
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, Agnieszka Hałoń
Agnieszka Hałoń,,
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, Marek Leśkiewicz (MISaF / IZM / KS)
Marek Leśkiewicz,,
- Katedra Statystyki
, Cyprian Kozyra (MISaF / IZM / KS)
Cyprian Kozyra,,
- Katedra Statystyki
, Rafał Matkowski
Rafał Matkowski,,
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Journal seriesAnticancer Research, ISSN 0250-7005, e-ISSN 1791-7530, (A 20 pkt)
Issue year2015
No35 (1)
Pages351-358
Publication size in sheets0.4
ASJC Classification1306 Cancer Research; 2730 Oncology; 2700 General Medicine
URL http://ar.iiarjournals.org/content/35/1/351.full?sid=d0446a0f-ed34-40a1-9cdf-510a9d88b120
Languageen angielski
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Donizy_Kaczorowski_Halon_Leskiewicz_Kozyra_Matkowski_Paucity_of_tumor2016.pdf 402,23 KB
Score (nominal)20
Score sourcejournalList
Publication indicators WoS Citations = 16; Scopus SNIP (Source Normalised Impact per Paper): 2015 = 0.679; WoS Impact Factor: 2015 = 1.895 (2) - 2015=1.892 (5)
Citation count*10 (2016-09-15)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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