High- and low-Molecular Weight oat Beta-Glucan Reveals Antitumor Activity in Human Epithelial Lung Cancer

Anna Choromańska , Julita Kulbacka , Joanna Harasym , Remigiusz Olędzki , Anna Szewczyk , Jolanta Saczko

Abstract

Beta-glucans are widely used in treatment, cosmetics, and the food industry. Glucans play a significant role in activation of the immune and antioxidant system and inhibiting tumor proliferation. In the current study the antitumor activities of new high and low molecular weight beta-glucan derived from oats were investigated in two human lung cancer cell line (A549, H69AR) and normal keratinocytes (HaCaT). The effect of high and low molecular weight beta-glucan from oat was evaluated by cellular viability assessment, lipid peroxidation and manganese superoxide dismutase evaluation and cytoskeleton visualisation. Additionally the level of red blood cells hemolysis was performed. Our results indicate strong anti-tumor properties of new beta-glucan from oat and at the same time no toxicity for normal cells.
Author Anna Choromańska - [Wroclaw Medical University]
Anna Choromańska,,
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, Julita Kulbacka - [Wroclaw Medical University]
Julita Kulbacka,,
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, Joanna Harasym (EaE / IChaFT / DBaFA)
Joanna Harasym,,
- Department of Biotechnology and Food Analysis
, Remigiusz Olędzki (EaE / IChaFT / DBaFA)
Remigiusz Olędzki,,
- Department of Biotechnology and Food Analysis
, Anna Szewczyk - [University of Wroclaw]
Anna Szewczyk,,
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, Jolanta Saczko - [Wroclaw Medical University]
Jolanta Saczko,,
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Journal seriesPathology & Oncology Research, ISSN 1219-4956, e-ISSN 1532-2807, (A 20 pkt)
Issue year2018
Vol24
No3
Pages583-592
Publication size in sheets0.5
Keywords in EnglishOat beta-glucan, Viability, Lung cancer, Keratinocytes, Oxidative stress, Cytoskeleton
ASJC Classification1306 Cancer Research; 2730 Oncology; 2700 General Medicine; 2734 Pathology and Forensic Medicine
DOIDOI:10.1007/s12253-017-0278-3
Languageen angielski
File
Choromanska_Kulbacka_Harasym_Oledzki_Szewczyk_Saczko_High_And_Low_Molecular.pdf 4,11 MB
Score (nominal)20
Score sourcejournalList
Publication indicators Scopus Citations = 10; Scopus SNIP (Source Normalised Impact per Paper): 2016 = 0.615; WoS Impact Factor: 2017 = 1.935 (2) - 2017=1.808 (5)
Citation count*15 (2019-12-05)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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