Antioxidative and anti-inflammatory effects of high beta-glucan concentration purified aqueous extract from oat in experimental model of LPS-induced chronic enteritis

Dominika Suchecka , Joanna Harasym , Jacek Wilczak , M. Gajewska , Michał Oczkowski , Sylwia Gudej , Katarzyna Błaszczyk , Dariusz Kamola , R. Filip , Joanna Gromadzka-Ostrowska


Contrary to most of studies concerning oat beta-glucan activity using non-purified oat milling fraction this study investigates aqueous extract of beta-glucan from oat (purity approx. 75%) with high (G1) and low (G2) molecular weight to verified its anti-inflammatory and antioxidant effects in a model of chronic LPS-induced enteritis. Chronic inflammatory bowel diseases, e.g. Crohn's disease (CD) and ulcerative colitis (UC) are expanding with the highest annual CD incidence in North America and the highest annual UC occurrence in Europe. The study has been conducted on Spraque-Dowley rats fed diets supplemented with 1% of G1 or G2 beta-glucan. Obtained results revealed that supplementation with both beta-glucan fractions led to significant reduction of different type blood leucocytes (lymphocytes T and B, granulocytes and lymphocytes Tc). Higher reduction of lipid peroxidation was observed in healthy rats after G1 supplementation, while G2 led this reduction in enteritis groups, mainly due to the increase of antioxidative defense.
Author Dominika Suchecka - Warsaw University of Life Sciences (SGGW)
Dominika Suchecka,,
, Joanna Harasym (EaE / IChaFT / KBŻ)
Joanna Harasym,,
- Katedra Biotechnologii Żywności
, Jacek Wilczak - Warsaw University of Life Sciences (SGGW)
Jacek Wilczak,,
, M. Gajewska - [Warsaw University of Life Sciences (SGGW)]
M. Gajewska,,
- Szkoła Główna Gospodarstwa Wiejskiego
, Michał Oczkowski - Warsaw University of Life Sciences (SGGW)
Michał Oczkowski,,
, Sylwia Gudej - Warsaw University of Life Sciences (SGGW)
Sylwia Gudej,,
, Katarzyna Błaszczyk - Warsaw University of Life Sciences (SGGW)
Katarzyna Błaszczyk,,
, Dariusz Kamola - Warsaw University of Life Sciences (SGGW)
Dariusz Kamola,,
, R. Filip - [Institute of Rural Health (IMW)]
R. Filip,,
- Instytut Medycyny Wsi im. Witolda Chodźki w Lublinie
, Joanna Gromadzka-Ostrowska - Warsaw University of Life Sciences (SGGW)
Joanna Gromadzka-Ostrowska,,
Journal seriesJournal of Functional Foods, ISSN 1756-4646, (A 45 pkt)
Issue year2015
Publication size in sheets0.5
Keywords in EnglishBlood leucocytes, Enteritis;, Inflammatory process, Lipid peroxidation, Oat beta-glucan, Rat
ASJC Classification2916 Nutrition and Dietetics; 2701 Medicine (miscellaneous); 1106 Food Science
Languageen angielski
Score (nominal)45
Score sourcejournalList
Publication indicators Scopus Citations = 17; WoS Citations = 17; Scopus SNIP (Source Normalised Impact per Paper): 2015 = 1.571; WoS Impact Factor: 2015 = 3.973 (2) - 2015=4.269 (5)
Citation count*26 (2020-07-10)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.