Antioxidative and anti-inflammatory effects of high beta-glucan concentration purified aqueous extract from oat in experimental model of LPS-induced chronic enteritis

D. Suchecka , Joanna Harasym , J. Wilczak , M. Gajewska , M Oczkowski , S. Gudej , K. Błaszczyk , D. Kamola , R. Filip , J. Gromadzka-Ostrowska

Abstract

Contrary to most of studies concerning oat beta-glucan activity using non-purified oat milling fraction this study investigates aqueous extract of beta-glucan from oat (purity approx. 75%) with high (G1) and low (G2) molecular weight to verified its anti-inflammatory and antioxidant effects in a model of chronic LPS-induced enteritis. Chronic inflammatory bowel diseases, e.g. Crohn's disease (CD) and ulcerative colitis (UC) are expanding with the highest annual CD incidence in North America and the highest annual UC occurrence in Europe. The study has been conducted on Spraque-Dowley rats fed diets supplemented with 1% of G1 or G2 beta-glucan. Obtained results revealed that supplementation with both beta-glucan fractions led to significant reduction of different type blood leucocytes (lymphocytes T and B, granulocytes and lymphocytes Tc). Higher reduction of lipid peroxidation was observed in healthy rats after G1 supplementation, while G2 led this reduction in enteritis groups, mainly due to the increase of antioxidative defense.
Author D. Suchecka - [Szkoła Główna Gospodarstwa Wiejskiego]
D. Suchecka,,
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, Joanna Harasym (EaE / IChaFT / KBŻ)
Joanna Harasym,,
- Katedra Biotechnologii Żywności
, J. Wilczak - [Szkoła Główna Gospodarstwa Wiejskiego]
J. Wilczak,,
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, M. Gajewska - [Szkoła Główna Gospodarstwa Wiejskiego]
M. Gajewska,,
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, M Oczkowski - [Szkoła Główna Gospodarstwa Wiejskiego]
M Oczkowski,,
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, S. Gudej - [Szkoła Główna Gospodarstwa Wiejskiego]
S. Gudej,,
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, K. Błaszczyk - [Szkoła Główna Gospodarstwa Wiejskiego]
K. Błaszczyk,,
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, D. Kamola - [Szkoła Główna Gospodarstwa Wiejskiego]
D. Kamola,,
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, R. Filip - [Institute of Rural Health]
R. Filip,,
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, J. Gromadzka-Ostrowska - [Szkoła Główna Gospodarstwa Wiejskiego]
J. Gromadzka-Ostrowska,,
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Journal seriesJournal of Functional Foods, ISSN 1756-4646, (A 45 pkt)
Issue year2015
No14
Pages244-254
Publication size in sheets0.5
Keywords in EnglishBlood leucocytes, Enteritis;, Inflammatory process, Lipid peroxidation, Oat beta-glucan, Rat
ASJC Classification2916 Nutrition and Dietetics; 2701 Medicine (miscellaneous); 1106 Food Science
DOIDOI:10.1016/j.jff.2014.12.019
URL http://www.sciencedirect.com/science/article/pii/S1756464614003983
Languageen angielski
Score (nominal)45
Score sourcejournalList
Publication indicators Scopus Citations = 17; Scopus SNIP (Source Normalised Impact per Paper): 2015 = 1.571; WoS Impact Factor: 2015 = 3.973 (2) - 2015=4.269 (5)
Citation count*20 (2019-12-05)
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