Prognostic significance of ALCAM (CD166/MEMD) expression in cutaneous melanoma patients

Piotr Donizy , Marcin Ziętek , Agnieszka Hałoń , Marek Leśkiewicz , Cyprian Kozyra , Rafał Matkowski

Abstract

ALCAM (activated leukocyte cell adhesion molecule, CD166, MEMD) is a transmembrane protein of immunoglobulin superfamily (Ig-SF) and plays an important role in human malignant melanoma progression and formation of locoregional and distant metastases. The study using melanoma cell lines showed that overexpression of ALCAM is directly related with the increase of cytoaggregation and the ability to form cell nests. The aim of the study was to assess the expression and intracellular localization of ALCAM in primary skin melanomas and metastatic lesions from regional lymph nodes. Also, prognostic significance of ALCAM expression in primary tumor cells and metastatic lesion cells was evaluated in the context of 5-year observation
Author Piotr Donizy - [Wroclaw Medical University]
Piotr Donizy,,
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, Marcin Ziętek - [Dolnoslaskie Centrum Onkologii, Wroclaw]
Marcin Ziętek,,
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, Agnieszka Hałoń - [Wroclaw Medical University]
Agnieszka Hałoń,,
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, Marek Leśkiewicz (MISaF / IZM / KS)
Marek Leśkiewicz,,
- Katedra Statystyki
, Cyprian Kozyra (MISaF / IZM / KS)
Cyprian Kozyra,,
- Katedra Statystyki
, Rafał Matkowski - [Dolnoslaskie Centrum Onkologii, Wroclaw]
Rafał Matkowski,,
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Journal seriesDiagnostic Pathology, ISSN 1746-1596, (A 30 pkt)
Issue year2015
Vol10
Pages1-11
Publication size in sheets0.5
Keywords in EnglishALCAM, Prognosis, Melanoma, Immunohistochemistry
ASJC Classification2700 General Medicine; 2722 Histology; 2734 Pathology and Forensic Medicine
DOIDOI:10.1186/s13000-015-0331-z
URL http://diagnosticpathology.biomedcentral.com/articles/10.1186/s13000-015-0331-z
Languageen angielski
LicenseJournal (articles only); author's original; Uznanie Autorstwa (CC-BY); after publication
File
Donizy_Zietek_Halon_Leskiewicz_Kozyra_Matkowski_Prognostic2015.pdf 1,69 MB
Score (nominal)30
Score sourcejournalList
Publication indicators WoS Citations = 13; Scopus Citations = 20; Scopus SNIP (Source Normalised Impact per Paper): 2015 = 1.094; WoS Impact Factor: 2015 = 1.895 (2) - 2015=1.933 (5)
Citation count*2 (2016-09-15)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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