Prognostic significance of ALCAM (CD166/MEMD) expression in cutaneous melanoma patients

Piotr Donizy , Marcin Ziętek , Agnieszka Hałoń , Marek Leśkiewicz , Cyprian Kozyra , Rafał Matkowski


ALCAM (activated leukocyte cell adhesion molecule, CD166, MEMD) is a transmembrane protein of immunoglobulin superfamily (Ig-SF) and plays an important role in human malignant melanoma progression and formation of locoregional and distant metastases. The study using melanoma cell lines showed that overexpression of ALCAM is directly related with the increase of cytoaggregation and the ability to form cell nests. The aim of the study was to assess the expression and intracellular localization of ALCAM in primary skin melanomas and metastatic lesions from regional lymph nodes. Also, prognostic significance of ALCAM expression in primary tumor cells and metastatic lesion cells was evaluated in the context of 5-year observation
Author Piotr Donizy - [Wrocław Medical University (UMW)]
Piotr Donizy,,
- Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu
, Marcin Ziętek - [Dolnośląskie Centrum Onkologii we Wrocławiu]
Marcin Ziętek,,
- Dolnośląskie Centrum Onkologii we Wrocławiu
, Agnieszka Hałoń - [Wrocław Medical University (UMW)]
Agnieszka Hałoń,,
- Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu
, Marek Leśkiewicz (MISaF / IZM / KS)
Marek Leśkiewicz,,
- Katedra Statystyki
, Cyprian Kozyra (MISaF / IZM / KS)
Cyprian Kozyra,,
- Katedra Statystyki
, Rafał Matkowski - [Dolnośląskie Centrum Onkologii we Wrocławiu]
Rafał Matkowski,,
- Dolnośląskie Centrum Onkologii we Wrocławiu
Journal seriesDiagnostic Pathology, ISSN 1746-1596, (A 30 pkt)
Issue year2015
Publication size in sheets0.5
Keywords in EnglishALCAM, Prognosis, Melanoma, Immunohistochemistry
ASJC Classification2700 General Medicine; 2722 Histology; 2734 Pathology and Forensic Medicine
Languageen angielski
LicenseJournal (articles only); author's original; Uznanie Autorstwa (CC-BY); after publication
Donizy_Zietek_Halon_Leskiewicz_Kozyra_Matkowski_Prognostic2015.pdf 1,69 MB
Score (nominal)30
Score sourcejournalList
Publication indicators WoS Citations = 13; Scopus Citations = 20; Scopus SNIP (Source Normalised Impact per Paper): 2015 = 1.094; WoS Impact Factor: 2015 = 1.895 (2) - 2015=1.933 (5)
Citation count*2 (2016-09-15)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.