Impact of purified oat 1-3,1-4-b-d-glucan of different molecular weight on alleviation of inflammation parameters during gastritis

Dominika Suchecka , Katarzyna Błaszczyk , Joanna Harasym , Sylwia Gudej , Jacek Wilczak , Joanna Gromadzka-Ostrowska


The antiinflammatory activity of purified oat 1-3,1-4-b-d-glucan against acute gastritis (sodium deoxycholate induced) model in rats was investigated as second part of experiment studying impact of oat b-glucan on inflammatory states in gastrointestinal tract (first part was related to enteritis). 48 rats (Spraque-Dawley males, two groups – control and gastritis) were fed high and low molecular weights (MW) b-glucan. Antioxidant defense parameters – SOD, TAS, GSH, GSSG and inflammation markers – TBARS, TNF-a, IL-10 and IL-12 were analyzed. Strong activity of both fractions was observed; high MW b-glucan caused high TNF-a decrease in both experimental groups while low MW b-glucan decreased the concentration of IL-10 in gastritis group. Both fractions significantly support innate antioxidant defense of stomach tissue not only in gastritis but in healthy state as well. The results reveal the potential therapeutic activity of purified oat b-glucan in acidic environment of stomach at acute gastritis states.
Author Dominika Suchecka - Warsaw University of Life Sciences (SGGW)
Dominika Suchecka,,
, Katarzyna Błaszczyk - Warsaw University of Life Sciences (SGGW)
Katarzyna Błaszczyk,,
, Joanna Harasym (EaE / IChaFT / DBaFA)
Joanna Harasym,,
- Department of Biotechnology and Food Analysis
, Sylwia Gudej - Warsaw University of Life Sciences (SGGW)
Sylwia Gudej,,
, Jacek Wilczak - Warsaw University of Life Sciences (SGGW)
Jacek Wilczak,,
, Joanna Gromadzka-Ostrowska - Warsaw University of Life Sciences (SGGW)
Joanna Gromadzka-Ostrowska,,
Journal seriesJournal of Functional Foods, ISSN 1756-4646, (A 45 pkt)
Issue year2017
Publication size in sheets0.5
Keywords in EnglishGastritis, b-Glucan, Oat, Antioxidant, Deoxycholate, Molecular weight
ASJC Classification2916 Nutrition and Dietetics; 2701 Medicine (miscellaneous); 1106 Food Science
Languageen angielski
Suchecka_Blaszczyk_Harasym_Gudej_Wilczak_Gromadzka_Impact_Of_Purified.pdf 1,28 MB
Score (nominal)45
Score sourcejournalList
Publication indicators Scopus Citations = 8; WoS Citations = 8; Scopus SNIP (Source Normalised Impact per Paper): 2017 = 1.281; WoS Impact Factor: 2017 = 3.47 (2) - 2017=3.767 (5)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.