Impact of purified oat 1-3,1-4-b-d-glucan of different molecular weight on alleviation of inflammation parameters during gastritis

D. Suchecka , K. Błaszczyk , Joanna Harasym , S. Gudej , J. Wilczak , J. Gromadzka-Ostrowska

Abstract

The antiinflammatory activity of purified oat 1-3,1-4-b-d-glucan against acute gastritis (sodium deoxycholate induced) model in rats was investigated as second part of experiment studying impact of oat b-glucan on inflammatory states in gastrointestinal tract (first part was related to enteritis). 48 rats (Spraque-Dawley males, two groups – control and gastritis) were fed high and low molecular weights (MW) b-glucan. Antioxidant defense parameters – SOD, TAS, GSH, GSSG and inflammation markers – TBARS, TNF-a, IL-10 and IL-12 were analyzed. Strong activity of both fractions was observed; high MW b-glucan caused high TNF-a decrease in both experimental groups while low MW b-glucan decreased the concentration of IL-10 in gastritis group. Both fractions significantly support innate antioxidant defense of stomach tissue not only in gastritis but in healthy state as well. The results reveal the potential therapeutic activity of purified oat b-glucan in acidic environment of stomach at acute gastritis states.
Author D. Suchecka - [Szkoła Główna Gospodarstwa Wiejskiego]
D. Suchecka,,
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, K. Błaszczyk - [Szkoła Główna Gospodarstwa Wiejskiego]
K. Błaszczyk,,
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, Joanna Harasym (EaE / IChaFT / DBaFA)
Joanna Harasym,,
- Department of Biotechnology and Food Analysis
, S. Gudej - [Szkoła Główna Gospodarstwa Wiejskiego]
S. Gudej,,
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, J. Wilczak - [Szkoła Główna Gospodarstwa Wiejskiego]
J. Wilczak,,
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, J. Gromadzka-Ostrowska - [Szkoła Główna Gospodarstwa Wiejskiego]
J. Gromadzka-Ostrowska,,
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Journal seriesJournal of Functional Foods, ISSN 1756-4646, (A 45 pkt)
Issue year2017
No28
Pages11-18
Publication size in sheets0.5
Keywords in EnglishGastritis, b-Glucan, Oat, Antioxidant, Deoxycholate, Molecular weight
ASJC Classification2916 Nutrition and Dietetics; 2701 Medicine (miscellaneous); 1106 Food Science
DOIDOI:10.1016/j.jff.2016.10.028
Languageen angielski
File
Suchecka_Blaszczyk_Harasym_Gudej_Wilczak_Gromadzka_Impact_Of_Purified.pdf 1,28 MB
Score (nominal)45
Score sourcejournalList
Publication indicators Scopus Citations = 8; Scopus SNIP (Source Normalised Impact per Paper): 2017 = 1.281; WoS Impact Factor: 2017 = 3.47 (2) - 2017=3.767 (5)
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